INTRODUCTION

Pharmacokinetics and pharmacodynamics of a drug depends on complex processes that are coded by different genes influencing drug transport, metabolism, and mechanism of action. When gene mutation and polymorphisms occur, the drug affinity towards metabolic activity or receptors also differs. More than 75% of the metabolic interactions of drugs are mediated through Cytochrome P450. We analyse the gene variant related to the ubiquitous P450 group of genes besides other relevant alleles. Among the various factors that influence expression and function of the enzymes to predict pharmacokinetics and drug response, monogenic polymorphisms play a major part in the variability of enzymes.

Datar Cancer Genetics Limited offers Pharmacogenetic testing that tests certain genes to determine how individuals will react to specific medications. This testing will help you to prescribe right medication and reduce risk of side effects.

Pharmacogenetics

About Pharmacogenetics testing

Drugs are a significant cause of morbidity and mortality, induced by Adverse Drug Reactions (ADRs). Although, till recently, the efficacy of drugs and their possible reactions were largely speculative for a given individual, recent developments in genetic sequencing technology and bioinformatics have lifted the veil of uncertainty.

Features of Pharmacogenetics

  • Provides insight into patient’s metabolic response
  • Surer, safer and selective drug therapy
  • Avoids Overdose / Underdose
  • Minimizes Adverse Drug Reactions (ADR)
  • Eliminates trial and error in therapy
  • Optimises therapeutic response
  • Affordable and once-in a-lifetime cost
  • Protects doctor from medicolegal complications

FOR WHOM?

PGx is useful for patients who

Are experiencing less than desired medication response

Are showing unwanted side effects

Take multiple medications due to medical comorbidities

Want to avoid adverse drug reactions (ADRs) and additional healthcare costs

Genetic polymorphisms influencing drug response

Need for personalized medicine

Drugs interact with specific targets localized in the plasma, on the cellular membrane or in cytoplasm for a clinical effect. In case of polymorphism or mutation, qualitative (e.g. in the amino acid sequence) or quantitative (in the levels of gene expression) modifications usually lead to commonly observed biological variability. In this scenario, a drug that is safe and efficacious in general population, may cause severe adverse effects in individuals carrying the disease gene.

HOW IT WILL HELP YOU?

When you combine PGx testing with your own medical expertise, you’ll be more confident that your patients are getting the most suitable medication for their needs, based on their genetics.

Insight into patient’s metabolic response

Surer, safer and selective drug therapy

Avoidance of Overdose / Underdose

Minimizes Adverse Drug Reactions (ADR)

Eliminates trial and error in therapy

Optimizes therapeutic response

Affordable and once-in-a-lifetime cost

Protects doctor from medico-legal complications

MEDICATIONS COVERED

Our PGx testing technology covers broad range of prescription and over-the-counter medications, and as such allows prescribers to incorporate an individual’s genetic profile to make better and more informed medication therapy decisions.

    Neurology / Psychiatry Drugs

  • Amitriptyline
  • Aripiprazole
  • Atomoxetine
  • Carbamazepine
  • Citalopram
  • Clobazam
  • Clomipramine
  • Clozapine
  • Desipramine
  • Doxepin
  • Escitalopram
  • Fluoxetine
  • Fluvoxamine
  • Haloperidol
  • Imipramine
  • Nortriptyline
  • Olanzapine
  • Paroxetine
  • Perphenazine
  • Pimozide
  • Risperidone
  • Sertraline
  • Thioridazine
  • Trimipramine
  • Venlafaxine
  • Zuclopenthixol
    Oncology Drugs

  • 5-Fluorouracil
  • Capecitabine
  • Carboplatin
  • Cisplatin
  • Tegafur
  • Cytarabine
  • Docetaxel
  • Doxorubicin
  • Gemcitabine
  • Irinotecan
  • Mercaptopurine
  • Methotrexate
  • Nilotinib
  • Oxaliplatin
  • Paclitaxel
  • Pazopanib
  • Pemetrexed
  • Tamoxifen
  • Thioguanine
  • Cyclophosphamide
  • Belinostat
    Immunosuppressive
    Drugs

  • Azathioprine
  • Tacrolimus
  • Mercaptopurine
  • Thioguanine
  • Sirolimus
    Antiretroviral Drugs

  • Abacavir
  • Efavirenz
  • Nevirapine
  • Tenofovir
    Other Drugs

  • Morphine
  • Opioids
  • Tramadol
  • Diclofenac
  • Celecoxib
    Antiviral Drugs

  • PEG-Interferon
  • Ribavirin
    Asthma & COPD Drugs

  • Salbutamol
  • Salmeterol
    Cardiovascular Drugs

  • Warfarin
  • Acenocoumarol
  • Carvedilol
  • Clopidogrel
  • Rosuvastatin
  • Aspirin
  • Simvastatin
  • Atorvastatin
  • Fluvastatin
  • Metoprolol
  • Perindopril

FAQS

Should everyone have pharmacogenetic tests performed?

Currently they are only indicated if a person is going to take, or is taking, a drug that has an accepted pharmacogenetic test associated with it.

How do pharmacogenetic tests differ from genetic tests?

Pharmacogenetic tests are performed to evaluate a person’s potential response to a drug therapy. Most genetic tests have been developed to help diagnose or predict the development of a genetic disease, for forensic medicine purposes, and in establishing parentage.