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BETTER
FASTER
ECONOMICAL

DIFFICULT CANCERS REQUIRE SMARTER STRATEGIES

  • Tumors have latent vulnerabilities that can be identified through ETA.
  • Agnostic to stage, grade, anatomy or morphology.
  • Integrational multi-analyte interrogation of tumor interactome and tumor function.
  • Tandem targeting of multiple vulnerabilities of the tumor using combination therapies to yield additive or synergistic benefits.

DIFFICULT CANCERS REQUIRE SMARTER STRATEGIES

  • Tumors have latent vulnerabilities that can be identified through ETA.
  • Agnostic to stage, grade, anatomy or morphology.
  • Integrational multi-analyte interrogation of tumor interactome and tumor function.
  • Tandem targeting of multiple vulnerabilities of the tumor using combination therapies to yield additive or synergistic benefits.
BETTER
FASTER
ECONOMICAL
SNVs/ INDELs
442 Genes
CNAs
417 Genes
FUSIONS
51 Genes
TMB
PDL1
MSI | MMR

Features

Targeted Therapy : Evaluation of companion diagnostic therapies across several cancer indications, and clinical trial matching across all solid tumors.
Immunotherapy : Helps inform immunotherapy decisions by including genomic signatures such as microsatellite instability (MSI), tumor mutational burden (TMB) and PDL1 status.
Simplified Report : All results are provided in a simplified report, with indications for approved therapies and genomic highlights.
452 Genes (SNVs, CNAs, Fusions and Indels).
Turnaround time is less than 3 working days from the day we receive the tissue sample.

Comparison

Platform Parameters FoundationOne CDx* Celldx
NGS Number of Genes 324 452
SNVs + Indels 309 442
SNAs 309 417
Fusions 36 51
TMB
MMR
HRD
IHC PD-L1
(optional)
STR | IHC MSI
Patient Benefits TAT 2 Weeks 48 Hours
Cost

* FoundationOne®CDx are registered trademarks of Foundation Medicine, Inc.

SNVs + INDELs

ARAFBRCA1BRCA2CDKN1BFANCIH3F3AHIST1H3BKNSTRNMAGOHMAXMED12NOTCH3POLERAC1RAD51RAD51BRAD51CRAD51DRHEBRHOARNF43SLX4SPOPSTAT3U2AF1

SNVs + INDELs + CNAs

ABL1ABL2ACVR2AADAMTS20AFF1AFF3AKAP9AKT1AKT2AKT3ALKAPCARARID1AARID2ARNTASXL1ATF1ATMATRATRXAURKAAURKBAURKCAXLBAI3BAP1BCL10BCL11ABCL11BBCL2BCL2L1BCL2L2BCL3BCL6BCL9BCRBIRC2BIRC3BIRC5BLMBLNKBMPR1ABRAFBRD3BRIP1BTKBUB1BCARD11CASC5CBLCCND1CCND2CCND3CCNE1CD79ACD79BCDC73CDH1CDH11CDH2CDH20CDH5CDK12CDK2CDK4CDK6CDK8CDKN2ACDKN2BCDKN2CCEBPACHEK1CHEK2CICCKS1BCMPK1COL1A1CRBNCREB1CREBBPCRKLCRTC1CSF1RCSMD3CTNNA1CTNNB1CYLDCYP2C19CYP2D6DAXXDCCDDB2DDIT3DDR2DEKDICER1DNMT3ADPYDDSTEGFREML4EP300EP400EPHA3EPHA7EPHB1EPHB4EPHB6ERBB2ERBB3ERBB4ERCC1ERCC2ERCC3ERCC4ERCC5ERGESR1ETS1ETV1ETV4EXT1EXT2EZH2FAM123BFANCAFANCCFANCD2FANCFFANCGFASFBXW7FGF19FGF3FGFR1FGFR2FGFR3FGFR4FHFLCNFLI1FLT1FLT3FLT4FN1FOXL2FOXO1FOXO3FOXP1FOXP4FZR1G6PDGATA1GATA2GATA3GDNFGNA11GNAQGNASGPR124GRM8GUCY1A2HCAR1HIF1AHLFHNF1AHOOK3HRASHSP90AA1HSP90AB1ICKIDH1IDH2IGF1RIGF2IGF2RIKBKBIKBKEIKZF1IL2IL21RIL6STIL7RING4IRF4IRS2ITGA10ITGA9ITGB2ITGB3JAK1JAK2JAK3JUNKAT6AKAT6BKDM5CKDM6AKDRKEAP1KITKLF6KRASLAMP1LCKLIFRLPHN3LPPLRP1BLTFLTKMAFMAFBMAGEA1MAGI1MALT1MAML2MAP2K1MAP2K2MAP2K4MAP3K7MAPK1MAPK8MARK1MARK4MBD1MCL1MDM2MDM4MEN1METMITFMLH1MLLMLL2MLL3MLLT10MMP2MN1MPLMRE11AMSH2MSH6MTORMTRMTRRMUC1MUTYHMYBMYCMYCLMYCL1MYCNMYD88MYH11MYH9NBNNCOA1NCOA2NCOA4NF1NF2NFE2L2NFKB1NFKB2NINNKX2-1NLRP1NOTCH1NOTCH2NOTCH4NPM1NRASNSD1NTRK1NTRK2NTRK3NUMA1NUP214NUP98PAK3PALB2PARP1PAX3PAX5PAX7PAX8PBRM1PBX1PDE4DIPPDGFBPDGFRAPDGFRBPER1PGAP3PHOX2BPIK3C2BPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIM1PKHD1PLAG1PLCG1PLEKHG5PMLPMS1PMS2POT1POU5F1PPARGPPP2R1APRDM1PRKAR1APRKDCPSIP1PTCH1PTENPTGS2PTPN11PTPRDPTPRTRAD50RAF1RALGDSRARARB1RECQL4RELRETRHOHRICTORRNASELRNF2RNF213ROS1RPS6KA2RRM1RUNX1RUNX1T1SAMD9SBDSSDHASDHBSDHCSDHDSEPT09SETD2SF3B1SGK1SH2D1ASMAD2SMAD4SMARCA4SMARCB1SMOSMUG1SOCS1SOX11SOX2SRCSSX1STK11STK36SUFUSYKSYNE1TAF1TAF1LTAL1TBX22TCF12TCF3TCF7L1TCF7L2TCL1ATERTTET1TET2TFE3TGFBR2TGM7THBS1TIMP3TLR4TLX1TNFAIP3TNFRSF14TNK2TOP1TP53TPRTRIM24TRIM33TRIP11TRRAPTSC1TSC2TSHRUBR5UGT1A1USP9XVHLWASWHSC1WRNWT1XPAXPCXPO1XRCC2ZNF384ZNF521

GENE FUSIONS

AKT2ALKARAXLBRAFBRCA1BRCA2CDKN2AEGFRERBB2ERBB4ERGESR1ETV1ETV4ETV5FGFR1FGFR2FGFR3FGRFLT3JAK2KRASMDM4METMYBMYBL1NF1NOTCH1NOTCH4NRG1NTRK1NTRK2NTRK3NUTM1PDGFRAPDGFRBPIK3CAPPARGPRKACAPRKACBPTENRAD51BRAF1RB1RELARETROS1RSPO2RSPO3TERT

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