Gastric
Doctor’s Prescription Required


RISK FACTORS
ASSOCIATED WITH CONVENTIONAL INVASIVE GASTRIC BIOPSIES
- Hemorrhage
- Accidental injury or perforation of nearby organs
- Problems with sedation or anesthesia
- Morbidity
RISK FACTORS
ASSOCIATED WITH CONVENTIONAL INVASIVE GASTRIC BIOPSIES
- Hemorrhage
- Accidental injury or perforation of nearby organs
- Problems with sedation or anesthesia
- Morbidity
Gastric
Doctor’s Prescription Required


TRUBLOOD®
Trublood® non-invasive diagnostic biopsy for solid organ cancers has been developed by Datar Cancer Genetics based on the findings of two clinical trials registered with the CTRI (Registration No. CTRI/2019/01/017219 and CTRI/2019/03/017918.
ADVANTAGES OF TRUBLOOD
- Blood based, Non-invasive
- Safe
- Accurate
- Easy on the Patient
- Reasonable Charges
- Available for all solid organs
WHO WILL BENEFIT
✓Symptomatic individuals who have been advised a biopsy to check for malignancy.
✓Patients where an invasive biopsy has been inconclusive or inconsistent with clinical observations.
✓Suspected metastatic relapse to rule out new primary.
RADIOLOGICAL SIGNS OF GASTRIC MALIGNANCIES
- Large epigastric mass.
- Focal wall thickening with mucosal irregularity.
- Gas-filled crater within the mass.
- Loss of normal rugal fold pattern.
IMMUNOCYTOCHEMISTRY
DIAGNOSTIC
EMT
THERANOSTIC
cfDNA+RNA
HOTSPOT GENES
COPY NUMBER GENES (CNVs)
GENE FUSIONS
MET exon 14 skipping
FISH
- ERBB 2
In Asia and Africa – cfDNA, FISH and Pharmacogenetics are optional and at extra cost
SPECIMEN REQUIREMENTS
BASIC DIAGNOSTICS
Thus, total 4 tubes containing 17 ml whole blood.
BASIC DIAGNOSTICS + cfDNA + RNA + FISH + PHARMACOGENETICS
Thus, total 5 tubes containing 25 ml whole blood.
✓Note :
- Sequence of draw should not be altered.
- Blood should be drawn only and only as per above method.
- Blood drawn should be performed only by qualified phlebotomist under medical supervision.
- Ship 4 °C in the container provided by DCG.
OTHER PRECAUTIONS PRIOR TO COLLECTION OF BLOOD SAMPLE
- The patient must not have received any form of cancer therapy (radiation / chemotherapy / surgery / endocrine etc.) at least 30 days prior to collection of sample.
- The patient must not have received oral or IV corticosteroids at least 14 days prior to collection of sample.
- Patient has no current febrile or any other acute inflammatory illness.
- Patient does not have acute exacerbation or flareup of an inflammatory condition requiring escalation in medical therapy at least 5 days prior to collection of sample.
- Patient has not received blood transfusion / PET-CT / CTscan at least 5 days prior to collection of sample.
- Patient is not positive for HIV / HBV / HCV.
7 EASY STEPS TO TRUBLOOD®


Our representative will contact you in 6 Hrs

You can ask our representative to help in selection of the most appropriate test


We can assist you with the logistics
(Please see our specimen requirement)


VALIDATION
Trublood has been extensively validated with data from more than 22,000 samples from asymptomatic individual donors who underwent currently used screening tests such as LDCT, Mammography, PAP Smear, Serum CA Markers and clinical examinations, as well as more than 18,000 samples from cancer patients / patients with benign conditions totalling more than 40,000 evaluable samples till December, 2019.
EVALUTED SAMPLES (PATIENTS)
Cancer Type | Patients |
---|---|
Breast | 3967 |
Head and Neck | 3552 |
Lung | 1378 |
Colorectal | 1341 |
Prostate | 1196 |
Cervix | 930 |
Ovary | 855 |
Esophagus | 507 |
Sarcoma | 440 |
Stomach | 392 |
Uterus + Endometrium | 365 |
Pancreas | 385 |
Liver | 381 |
CNS | 349 |
Kidney | 342 |
Bladder | 249 |
Bone | 220 |
Gallbladder | 196 |
Thyroid | 175 |
Testes | 135 |
Skin | 115 |
Melanoma | 86 |
Penis | 72 |
Neuroendocrine | 51 |
Others | 154 |
Total | 17,833 |
Particulars | Samples |
---|---|
All Cancers | 17,833 |
Benign Conditions | 488 |
Asymptomatic Individuals | 22,030 |
Total | 40,351 |
SUMMARY

BASIS
- Tumors release thousands of cells into the circulation, where circulating tumor cells (CTCs) survive for about 1–2.5 hours.
- In order to detach from the primary tumor and disseminate into the blood, cells must undergo a cellular process known as Epithelial-Mesenchymal Transition (EMT).
- EMT enhances migratory capabilities of tumor cells, which allows cells to penetrate into the vasculature and circulate as single or clusters of circulating tumor cells (CTCs).
- CTCs extravasate having undergone the reverse process known as Mesenchymal to Epithelial Transition (MET) and colonize at distant organs.
- Circulating Tumor Cells (CTCs) are defined as EpCAM (+), PanCK (+), CD45 (-) cells. Circulating Tumor Associated Cells (C-TACs) are EpCAM(+), PanCK(+), CD45(+/-) cells of tumorigenic origin, in peripheral blood.
- Non-tumorigenic cells in peripheral blood have functional apoptotic mechanism, but CTC and C-TACs are resistant to apoptosis.
- An epigenetically active stabilizing process can eliminate normal cells and confer survival privilege on apoptosis – resistant C-TACs, CTC and C-TACs.
- Sufficient C-TACs can be enriched and harvested for Immunocytochemistry (ICC) profiling with markers used in immunohistochemistry (IHC) which aid in determination of histopathological subtypes of tumor tissue.
- Antibody clones used in the trublood® assay for analysis of tumor antigens/markers are internationally approved for IVD use.
DOWNLOAD BROCHURE + SAMPLE REPORT
FREQUENTLY ASKED QUESTIONS
Can Trublood® detect all cancers?
Trublood® detects presence of carcinoma i.e. epithelial malignancies, melanoma as well as certain subtypes of sarcoma. It does not detect haematolymphoid malignancies. Carcinomas are the most common malignancy in adults.
Can Trublood® differentiate between squamous cell carcinoma and adenocarcinoma?
Can Trublood® always provide specific histopathological subtype? Can it identify rare HPE subtype?
Can Trublood® give us the histological grade of the tumor?
What is the principle used in Trublood®?
How is Trublood® different from a Circulating Tumor Cell (CTC) test?
Can I use Trublood® for longitudinal CTC enumeration?
Can you find CTCs in blood when there is Carcinoma in situ? / Can Trublood® identify carcinoma in situ?
Can you find CTCs in early stage cancer?
How does it give guidance for therapy?
How does it differ from other cancer screening methods e.g. CA125, CA19-9, etc.?
Can Trublood® be offered to a person with non-specific cancer symptoms such as cachexia without clinical suspicion of a particular organ involvement?
How is the sample collected? Is there any special procedure for collection?
How is the sample transported?
What is the next step if Trublood® gives positive result?
Do I need to confirm the presence of malignancy with an invasive biopsy when Trublood® results are positive?
Do you have any comparative data?
How is the performance of Trublood®? What is the validation you have for this test?
Is it being used by clinicians anywhere?
What if the test is inconclusive?
Can Trublood® be availed for childhood malignancies?
What advantage does Trublood® offer over tissue biopsy?
What are the limitations of Trublood®?
Can Trublood® give theragnostic information similar to that obtained by tissue biopsy?
Will doctor treat me based on Trublood® result?
Can Trublood® be used in haematological malignancies?
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